5 Facts you should know about

Pulmonary alveolar proteinosis (PAP)

The cardinal signs and symptoms of PAP include shortness of breath, cough, low-grade fever, and weight loss

PAP is characterized by an abnormal accumulation of surfactant-derived lipoprotein compounds within the alveoli

The abnormal accumulation of lipoproteinaceous compounds in PAP is due to impaired surfactant regulation and clearance

Anti–GM-CSF antibodies are believed to play a role in PAP

Individuals with PAP are more vulnerable to lung infections, such as bacterial pneumonia, AND mycobacterial or fungal infections

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